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For example, using peptides together with medicines metabolized by cytochrome P450 can lead to increased levels of these medicines in the blood, which may raise the risk of side effects

If needed, the day of weekly administration can be adjusted, provided there is at least a 3-day (72-hour) interval between doses

However, when constipation persists despite these measures, or when it causes significant discomfort or distress, pharmacological intervention may be appropriate

Overall, these results indicate that within one week of exposure to 100 dB noise, the mice exhibited behavioral evidence of tinnitus, despite no significant hearing loss