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Since 5HT is a powerful vasoconstrictor (29), a smooth muscle mitogen (30), and cardiovascular instability is associated with acute MDMA lethality (31), we used 1 H-MRS and HPLC to determine the effect of MDMA on the cardiac metabolic profile and monoamine levels in rats treated with MDMA

Research suggests that the medication, a glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, originally developed to manage Type 2 diabetes, may be able to treat a wide range of conditions involving impulse control, like binge eating disorder.But although there may be tantalizing clues for helping patients with unwanted impulses, GLP-1 and GIP inhibitors may not be optimally designed to treat them sufficiently and need further research, according to a case study from the Perelman School of Medicine at the University of Pennsylvania, published today in Nature Medicine

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