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Celiac and the cranial mesenteric arteries supply gastrointestinal sites that regulate meal size and intermeal interval length via cholecystokinin-58 in male rats

Clinically, elevated IS levels correlate strongly with increased cardiovascular event incidence in patients with CKD, primarily mediated by inducing oxidative stress in endothelial cells (Lin et al., 2012

In women with PCOS and obesity, studies of GLP-1 receptor agonists have demonstrated reductions in elevated androgen levels, including testosterone, along with improvements in menstrual regularity and ovulation rates

These combined actions underscore their therapeutic potential for NAFLD (89, 90)