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If the GLP-1/GIP/glucagon receptor class shows disease-modifying behaviour in OA rather than just mechanical pain relief from weight loss, it expands the scientific rationale for the compound and reinforces the argument that the triple-agonist mechanism is doing more than suppressing appetite

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Previously, these treatments required patients to self-administer injections on a regular basis, which could be a barrier to adherence for many individuals

Clinical trial data shows that lean mass loss occurs in most participants on semaglutide and tirzepatide, with estimates ranging from 25% to 40% of total weight lost