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IL-6 binds to TGF- to activate the STAT3 signaling pathway [20], inducing the expression of Th17 cell-specific principal transcription factor retinoic acid receptor-related orphan receptor gamma-t (RORt), thus differentiating into Th17 cells rather than Treg cells

As noted, however, the peptide has exhibited minor to no side effects when administered to both animal subjects and humans, across a variety of research settings and dosages

This is partly a result of insulins effects on hepatic GHR expression, and partly a post-receptor signaling effect as unraveled by extensive animal studies (reviewed in (60)

Chapter 6 - normal and epilepsy-associated pathologic function of the dentate gyrus, in Progress in brain research