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Elevated CHAC1 expression in LUAD correlates with aggressive tumor progression and poor patient prognosis ( CHAC1 upregulation marks advanced disease states ( CHAC1 upregulation in renal cell carcinoma (RCC) is linked to advanced tumor stage and higher histological grade, suggesting its role in cancer progression and malignancy ( The elevated CHAC1 expression in LUAD promotes tumor proliferation and metastasis by enhancing glycolysis, lactate production, and ATP generation through regulation of pyruvate kinase M2 (PKM2)

This is illustrated in vitamin C, which does not allow the formation of nitroso compounds (359)

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