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Even epilepsy and panic disorder share some clinical features with CVS and it is important to stress that the autonomic manifestations are prominent (or even isolated) features in some epilepsy with onset in pediatric age such as PS and rolandic epilepsy, requiring sometimes a challenging differential diagnosis (70, 71)

doi: 10.1210/edrv-12-3-252

Regulatory Responses & Clinical Implications Regulatory bodies, including FDA and state healthcare committees, have begun addressing the off-label surge

Metabolic disruption increases the risk of menstrual irregularity, ovulatory infertility, and adverse pregnancy outcomes