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identified the batch effect as one of the most critical issues in metabolomic applications when used for screening purposes ( Despite the importance of the use of QC in untargeted metabolomics, few authors make use of this correction (Moreno-Torres et al., 2021

The only cross-compound evidence that exists is indirect : network meta-analyses that statistically connect drugs through their shared comparators (usually placebo) rather than through direct comparison

Davies M, Frch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L et al