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A few GLP-1 agonists currently in phase 3 trials are higher-dose injectable semaglutide 7.2 mg (Novo Nordisk), oral semaglutide 50 mg (Novo Nordisk) and orforglipron (Eli Lilly)

Multi-agonist therapies combining GLP-1 with GIP or glucagon may amplify these benefits by improving fat metabolism and reducing cardiovascular risk even further

The primary source of cystine in GSH synthesis is available through the cystine-glutamate antiporter xCT

2.7 Statistical analysis For the meta-analysis, only studies reporting comparable dichotomous data on AMS incidence between participants receiving antioxidant treatment and those assigned to placebo or control were included