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Additionally, GLP-1RA is associated with gastrointestinal adverse events, which may cause absorption of minerals and nutrients and thereby interfere with the beneficial function of GLP-1RA on bone physiology ( It is possible that different GLP-1 agents have divergent effects on bone fractures, as shown in another meta-analysis of RCTs that ended in December 2013

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Furthermore, internal infusion of 30 mol/L mastoparan, a peptide activator of G i and G o , for 6 min did not change the GABA currents of GCs (control), and in the presence of mastoparan, applying exendin-4 for 6 min still suppressed the GABA currents to 76.85% 4.54% of control ( P 0.05 vs 8-Br-cAMP) (Fig