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AstraZeneca puts a lot of money into research and more advanced therapeutic technologies, so that patient outcomes get better and treatment efficiency improves

For example, Mendelian randomization analysis using genetic instrumental variables was used to help validate some of the derived proteomic signatures for specific traits

The FDA's approved indication recognizes two pathways: a BMI of 30 or higher, or a BMI of 27 or higher combined with at least one weight-related health condition like type 2 diabetes or hypertension