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The agency said it intends to take steps to restrict GLP-1 active pharmaceutical ingredients (APIs) intended for use in non-FDA-approved compounded drugs that are being mass-marketed by companies, including Hims & Hers and other compounding pharmacies, as similar alternatives to FDA-approved drugs. This led Hims & Hers to halt sales of certain, lower-cost, non-FDA-approved, copycat versions of drugs like Wegovy and Ozempic

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These medications are used for chronic weight management and treating type 2 diabetes

Administration of the DPP-4 inhibitor, PKF275-055 (3 mg/kg/day), or linagliptin in STZ-induced diabetic rats inhibited macrophage infiltration, inflammatory molecules, and NF- B activity in the glomeruli [105] and significantly reduced glomerular leukocyte infiltration [106]