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Thus, sustained PERK pathway activation integrates proteostasis control with angiogenic and invasive programs, positioning this UPR branch as a central driver of tumor progression rather than a mere stress-response mechanism
May 2007
Validating urine-based biomarkers (e.g., cyst-derived exosomal ferroptosis regulators and lipid peroxide metabolites) or circulating signatures that correlate with ADPKD disease stage, cyst growth rate, or response to ferroptosis modulators is urgently needed to guide clinical trial design and patient stratification
A cloudy solution usually indicates incomplete dissolution or peptide degradation
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