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Description

This secondary analysis focused on heart health in the first six months after participant randomization

diagnosis requires skin punch biopsy for intraepidermal nerve fiber density (IENFD) or quantitative sensory testing

After completion, as monitored by UPLC and ESI-LCMS, the reaction mixture was diluted with buffer A, filtered and purified directly by preparative RP-HPLC, eluting with a linear gradient (see the Peptide cleavage and purification section)