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While, our panel effectively captured all regions with known pathogenicity, it did not include all intronic sequences, which may harbor regulatory or splicing-disrupting variants potentially relevant to disease pathogenesis

52 Among patients undergoing bio-enteric IGB placement, the prevalence of hypertension, diabetes, hypercholesterolemia, and osteoarthropathy decreased from 29%, 15%, 32%, and 25% (pre-IGB), respectively, to 16%, 10%, 21%, and 13% at 3 years post-IGB removal

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These neuroprotective effects were linked to suppression of paraquat-induced activation of the MAPK signaling cascade, a pathway known to mediate oxidative and apoptotic damage in dopaminergic systems