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The most commonly reported side effects are mild and transient: injection site redness or minor bruising, transient fatigue in the first one to two weeks, and occasionally mild headache following the first few injections, a pattern sometimes attributed to the acute shift in cellular energy metabolism as AMPK pathways are upregulated [3]

When choline intake falls short, this phospholipid can be synthesised from phosphatidyl ethanolamine, but incurs severe pressure on the universal methyl donor, SAM (Figure 2) (169)

both systolic and diastolic), body mass index (BMI), fibrinolytic activity, waist-hip ratio, and enzymatic activity (catalase [CAT], superoxide dismutase [SOD], and glutathione peroxidase [GPx])