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These findings help to explain why leptin replacement does not completely reverse the neuroendocrine adaptations induced by weight loss 1, 3, 5 , since both GH and leptin play a role informing the brain about energy deficiency

To compare the different results, the amount of GAGs was related to the amount of total protein in the sample

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Metabolic flexibility Although glutamine is the primary carbon source for the TCA cycle in some cancer cells, replenishment of TCA cycle intermediates using alternative anaplerotic substrates reduces bioenergetic stress, thereby enabling resistance to inhibition of glutamine metabolism