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The reversible interconversion of serine and glycine is catalyzed by, either the cytosolic or mitochondrial serine hydroxymethyltransferase (SHMT), SHMT1 or SHMT2, respectively, of which the latter is most prominently expressed in cancer [12,13,14,15]

Including ChaC1 in tumor prognosis predictions may guide personalized treatment options

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Excessive testosterone production in PCOS is mainly due to the increased release of luteinizing hormone by the pituitary gland and the effects of a hyperinsulinemic state on the ovaries