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Consistent with our data identifying different regulation of incretin bioactivity and modulation of glucose metabolism with DPP4 in hepatocytes versus Tie2 + cells, recent reports have determined that elevated levels of active portal GLP-1 are disconnected from the classic definition of the incretin effect as increased portal circulation of GLP-1 does not potentiate nutrient-stimulated insulin secretion (64, 65)
In another study of similar design, 1000 mg of vitamin C taken daily for 4 weeks bolstered vitamin E and glutathione content in erythrocyte cell membranes, compared with placebo
Precautions should be taken for individuals with certain medical conditions, such as pancreatitis or thyroid issues
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