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Conversely, protective factors include long-term stable therapy (greater than 3 months) due to tachyphylaxis effects, asymptomatic patients without gastrointestinal complaints, properly timed medication cessation when indicated, and absence of additional gastroparesis risk factors [13]

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2023 titled Further evidence of relationship between thiamine blood level and cognition in chronic alcohol-dependent adults: Prospective Pilot Study of an inpatient detoxification with oral supplementation protocol, improvements in cognition and thiamine blood levels have been observed over about 14 days of supplementation

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