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Amino acid profiling siblings discordant for konzo identifies deficiencies in key sulfur amino acids and suggests mitochondrial distress To determine if siblings discordant for konzo had major differences in amino acid profiles which may contribute to changes in GPx3 abundance, we used an HPLC-based approach to quantify plasma amino acids in samples from study participants

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1 Originally FDA-approved for type 2 diabetes, GLP-1 RAs also lead to sustained weight loss and have revolutionized diabetes and obesity management