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doi: 10.1111/apha.12445 170 FehrEPongorAltdorferKKboriLLengyelG

16 hr half life desipramine (generic, Norpramin ) is an active metabolite of imipramine that selectively inhibits NET, with minor effects on SERT

A double-blind, randomized, placebo-controlled trial in 130 PCOS patients showed the combination of letrozole plus 1,200 mg NAC per day resulted in more follicles greater than 18 mm in diameter (a size associated with greater likelihood of ovulation) after five days than letrozole alone or placebo

These are not necessarily distinct stages of evolution of disease, but rather, multiple stages that may be present simultaneously in a given individual