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In the rat model, bidirectional effects on nitric oxide synthases have been observed: stimulation of the endothelial form (eNOS) with simultaneous inhibition of the inducible form (iNOS), suggesting a role in maintaining vascular homeostasis

Tesamorelin (a component of the stack) Tesamorelin + Ipamorelin) is the only individual component with FDA approval, but only for its specific indication (HIV lipodystrophy, as monotherapy)

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Active cancer is a contraindication for most growth-factor-adjacent peptides because we do not want to fertilize a tumor we do not know about