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There appears to be no age-related increase in GH sensitivity to IGF-Is negative feedback (17)

If pregnant, breastfeeding, on medication, or under medical supervision, consult your doctor before use

Adverse effects such as tachycardia, infections, headaches, dizziness, nausea, vomiting, diarrhea, and dyspepsia, as well as contraindications such as a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, hypersensitivity, severe gastrointestinal diseases, renal impairment, and pregnancy have been noted

The assessment of these studies revealed that WL following bariatric surgery varied significantly, with reductions ranging from 3.6% to 66.7%