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GLP-1 Drugs and Triathlon Performance: What Ozempic Really Does to Athletes May 15, 2026 GLP-1 medications like semaglutide (Ozempic, Wegovy) can significantly affect triathlon performance by suppressing appetite, slowing gastric emptying and increasing the risk of muscle loss and chronic under-fuelling

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The activation of GPER has been reported to stimulate the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway [121, 122], resulting in the upregulation of the expression of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) [123]

"FDA may still take action regarding violations of any other statutory or regulatory requirements, such as to address findings that a product may be of substandard quality or otherwise unsafe," the spokesperson said