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Both the 2016 consensus statement of the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) on management of type 2 diabetes and the 2016 American Diabetes Association (ADA) standards recommend adding on GLP-1 RAs to patients not meeting treatment goals with basal insulin

About 12.0% of people taking Rybelsus had a major heart-related event such as a heart attack, stroke, or heart-related death compared to 13.8% of those taking a placebo

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The lactam-cyclized heptapeptide is based on the structure of MT-II, only differing in structure by the lack of C-terminal amide (106)