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The standard body surface area scaling method, endorsed by the FDA for first-in-human dose estimates, typically divides the rodent dose by a factor of approximately 6.2 when converting from rat to human

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The tight negative feedback control that glutathione exerts on the first of two enzymes responsible for glutathione synthesis, GCL, can explain this phenomenon

While probably not perfectly accurate, this is a great feature to use when the points arent available, like restaurants, parties, or when you are simply in a hurry