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All materials should be handled by qualified personnel in accordance with applicable laboratory safety and regulatory requirements

Performed the experiments: TK, YH, YS, TK, TK, YO, WT, KI, KF, MY, YS, ST, SS, MO, SO, YE, YI, WA, KS, and AN

6 Clinical research and future perspectives 6.1 Expansion trends in clinical indications At present, the most established clinical applications of riboflavin are in FAD responsive metabolic disorders such as RTD and MADD