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According to the Summary of Product Characteristics (SmPC), semaglutide undergoes metabolism in the liver with metabolites excreted via urine and faeces in roughly equal proportions, with minimal unchanged renal excretion

The gradual dose escalation schedule is specifically designed to minimise these moving up doses too quickly is the main reason gastrointestinal side effects become difficult to manage

Share your genetic test results with your healthcare provider to inform discussions about semaglutide dosing, timing, and whether your metabolic profile suggests any need for individualized handling or administration protocols

And its focus on fewer treatments has allowed it to expand its available medication formats faster than others