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Studies have shown that GLP-1 medications can lead to significant reductions in body weight, improve overall health profiles, and lower the risk of health issues related to blood pressure and cholesterol

However, split-dosing protocols for similar incretin-based peptides show that dividing the dose does reduce peak blood levels by approximately 15-25%, which correlates with reduced gastrointestinal side effects in some individuals

The trial used a flexible dosing protocol, permitting investigators to adjust doses based on individual tolerability and clinical judgement

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