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Interference with processes such as TGF--mediated fibroblast activation and the production of ECM proteins by fibroblasts that transform into myofibroblasts disrupts the fundamental mechanism of cardiac fibrosis 7,9,10,75

Metformin alone promoted apoptosis in U87 and T98G cells, but had no significant effect on HEB cells

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The enzymatic activity of prolyl 4-hydroxylase subunit alpha 1 (P4HA1), a procollagen-proline, 2-oxoglutarate 4-dioxygenase, is crucial for collagen polypeptide chain folding into stable triple-helical molecules and consequently for ECM deposition [23]