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A systematic review was consistent with our results: gastrointestinal toxicities tended to occur early after treatment initiation with fluctuation over time, both in a type 2 diabetic population and a more general population ( To further assess the severity of gastrointestinal AEs related to different GLP-1RAs, the severe proportion was compared among different GLP-1RA treatments

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Excess iron can also be stored by binding to ferritin, which can be lysosomally degraded to increase intracellular free iron levels, thus inhibiting the ferritin (FTH) degradation process would limit ferroptosis (16)

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