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For chronic conditions such as gut healing or general tissue repair, once-daily dosing is often sufficient

doi: 10.1016/j.scitotenv.2017.11.048 84 GhisariMBonefeld-JorgensenEC

596 The simultaneous effects of impaired NAD + biosynthesis and over depletion of NAD + by PARPs can lead to a decrease in the level of NAD + in the kidney during AKI