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Expression of the Drosophila homeobox gene, Distal-less, supports an ancestral role in neural development

PMID: 33260933[PubMed Reference] Chang CH, Tsai WC, Lin MS, et al

However, native GLP-1 undergoes rapid enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), resulting in a short half-life (~ 2 min), thus limiting its clinical applicability [65, 66]

[22] Some of these metabolic improvements may occur partly independently of weight loss, as suggested by mediation analyses from cardiovascular outcome trials, potentially reflecting effects on insulin sensitivity and vascular health that may be relevant for patients with obesity-related comorbidities like sleep apnea