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These LC neurons receive projections from pre-proglucagon expressing neurons, indicating a possible role in the physiologic control of food intake by the endogenous GLP-1 system
GLP-1 analogs could reduce the risks of microvascular complications of DM and are recommended for patients with cardiovascular disease or diabetic kidney disease in the American Diabetes Association (ADA) Standards of Medical Care in Diabetes-2020 (American Diabetes Association, 2020a
These patients had newly filled prescriptions for GLP-1 RAs, dipeptidyl peptidase-4 (DPP4) inhibitors, sodium-glucose cotransporter 2 (SGLT2) inhibitors or sulfonylurea between January 2014 and December 2021
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