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If accepted, they assign a PDUFA date and review begins officially

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The reason for this is that they start to develop their internal day-night (circadian) rhythm that favours sleep at night and being more awake during the day

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GLP-1 (glucagon-like peptide-1) is a naturally occurring hormone produced in the intestines that regulates blood sugar and appetite but lasts only 1-2 minutes in the body

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