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We also observed strong LAG-1::HA staining in nuclei of all somatic gonad cells, the DTC, and all sheath and spermathecal cells, as well as in polyploidy intestinal cells, in both the L4 and adult stage dissection preparations

To induce obesity (770 g mean body weight at the start of the experiment), rats on Chow + HFSD also received two Nabisco Golden Oreo cookies per day in addition to ad libitum food access

Studies have shown that people tend to lose more weight on tirzepatide than other GLP-1s, likely because of the dual action.* *Tirzepatide as Compared with Semaglutide for the Treatment of Obesity, New England Journal of Medicine, July 2025

A lower or less frequent dose of fluoxetine should be used in patients with cirrhosis