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The researchers published their findings from the STEP 1 trial in the February 2021 New England Journal of Medicine

Initial studies reported that concentrations of AFB 1 which are likely to be achieved in the liver following ingestion of real-world concentrations of AFB 1 are bioactivated to AFBO primarily by CYP1A2, whereas much higher concentrations are catalyzed by CYP3A4 [30], [46], [79]

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