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Although a number of therapeutic approaches have been used for women with presumed extrapelvic endometriosis, the reported efficacy of ovarian suppression with a GnRH agonist appears to support it as the first line of therapy except in cases of obstruction of the ureter or bowel, which are best treated surgically (38)

reported a hypoxia-sensitive prodrug conjugate 5E , by the combination of anticancer drug SN38, cancer-targeting biotin, and hypoxia-sensitive self-immolative linker 4-nitrobenzyl, for the diagnosis and treatment of solid tumors 126

By protecting mitochondrial membranes from oxidative damage, glutathione may help maintain the liver's metabolic capacity

Dose-response curves for the glutathione assay show that Phenylbutazone (Fig