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Abbreviations ALL: Acute lymphoblastic leukemia Met: Metformin CQ : Chloroquine AraC : Cytarabine MDA : Malondialdehyde FRAP: Ferric reducing antioxidant ability DPPH: 2,2-Diphenyl-1-picrylhydrazyl allo-HSCT : Allogeneic hematopoietic stem cell transplantation CAR-T: Chimeric antigen receptor T-cell WHO: World Health Organization AMPK : Adenosine monophosphate-activated protein kinase HDF: Human dermal fibroblast FBS : Fetal bovine serum PBS: Phosphate-buffered saline FITC: Fluorescein isothiocyanate PI: Propidium iodide qRTPCR: Quantitative real-time polymerase chain reaction TAC: Total antioxidant capacity GSH: Reduced glutathione GSSG : Oxidized glutathione OD: Optical density DTT: Dithiothreitol HCQ : Hydroxychloroquine PARP: Poly ADPribose polymerase References Dander, E., Palmi, C., DAmico, G

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Upon low pH exposure, the acetal hydrolysis resulting in conversion of amphiphilic system to hydrophilic polymer again and subsequently significant breakage of micelles and release of the encapsulated guest