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The anesthesia effect is reversible, lasting for a certain time depending on physicochemical properties

Our previous study demonstrated that a 14-day daily administration of lenvatinib to rats reduced OCTN2 protein levels in the skeletal muscle and intestine, but not in the kidney, and consequently decreased L-carnitine content in the skeletal muscle (Jing et al., 2022)

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This can lead to steroid-induced hyperglycaemia in people without diabetes, or significantly worsen glycaemic control in those with pre-existing type 2 diabetes