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Short-Peptide Design The AEDG tetrapeptide was designed as a chemically defined sequence intended to reproduce selected activities attributed to the pineal extract

Consistent with this prevention first appeal (182, 184), EU policymakers have already identified and emphasized (i) the urgent need for greater and more pressing efforts toward a shift to the prevention of ill-health and disease with health promotion as a key pillar in ensuring future public health (114, 118), and (ii) the cross-European need to focus on changes in future medical and health pedagogy to address the current public health gaps (262, 290)

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Rapid inactivation of these incretin hormones by DPP-4 leads to an insufficient release of insulin following oral glucose intake [31] and many of the physiological signs of T2DM, such as deteriorating glycemic control, are secondary to incretin inactivation by DPP-4