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Certain medications which can trigger pigmentation as a side effect
The peptide prevents both excessive proteolysis that impairs healing and insufficient matrix turnover that creates rigid, dysfunctional scar tissue
77,83,84 In addition, the expression of ALDH1L2 is upregulated by some certain drugs, such as thapsigargin and tunicamycin, endoplasmic reticulum stress inducers in immortalized human B cells, 85 mitotane, an adjuvant monotherapy used for treating adrenocortical carcinoma, 86 and the indomethacin, an anti-inflammatory agent in breast cancer cells
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