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Researchers sought to develop a peptide capable of stimulating endogenous growth hormone release while minimizing activity at pathways associated with other pituitary hormones

Endocrinol Diabetes Metab Case Reports

Tirzepatide administration was shown to alleviate hepatic steatosis in mouse models of MASLD induced by high-fat diets (HFD) or high-fat, high-fructose, and high-cholesterol (HFFC) diets, as evidenced by the reduction in liver weight, hepatic pallor, associated pathological changes, and hepatic lipid accumulation

At the same time, GIP antagonists have been proposed to improve insulin sensitivity by preventing the development of obesity in rodents, but, similarly, such compounds have not yet been tested in patients with diabetes or obesity