It also supports nerve function and cognitive health, making it important for mental clarity and focus
JAMA 331(1):3848 Lincoff AM, Brown-Frandsen K, Colhoun HM et al (2023) Semaglutide and cardiovascular outcomes in obesity without diabetes
each 10% reduction in homocysteine is associated with 1.45-2.55 reduction in pulse pressure mmHg in patients undergoing hemodialysis (14)(27)(31) Increased urinary excretion of homocysteine in its sulfonated form (36) Omega-3 fatty acids 200-6,000 mg (~98-2,000 mg EPA/490-1,000 mg DHA) per day, for 1-12 months in patients with hyperhomocysteinemia or elevated homocysteine within normal ranges (8)(11)(13)(17)(18)(19)(25)(30)(42)(43) Reduced homocysteine by 1.18-1.58 mol/L on average using wide dose ranges, as shown in meta-analyses (8)(18) Reduced homocysteine by ~2.5-4.0 mol/L in patients with type II diabetes, patients on hemodialysis, or healthy adults using mid-range doses of 2,000-3,600 mg per day for 1-3 months and up to one year (11)(17)(25)(30)(42)(43) Reduced homocysteine by ~1.6 mol/L over 12 months in patients younger than 65 years, previously suffering from myocardial infarction (13) Adjunct therapy with folic acid, vitamin B6, and vitamin B12 improved efficacy (8)(17) Adjunct aerobic exercise and cognitive stimulation may be required for benefit in some populations, including older adults with mild cognitive impairment (19)
the gut will pick up an increasingly smaller % of the nutrient - from the supplement and from the diet too - true for almost all water soluble vitamins and many minerals therefore more will be left unabsorbed in the lumen, changing the medium for your microbiome, which may have positive negative or neutral net effects these bigger doses can turn this nutrient into a 'bully' negatively interfering with the uptake, and/or distribution or retention of other nutrients you can induce a dependency on mega-doses for that individual your original nutrient goals get further away not closer or you can induce an excess and toxicity issues for those micronutrients not adhering to the pattern above So, are you ready for a total rethink about how to prescribe nutrition
