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Overall, these data suggest that additional lipases may support BAT function, and that a whole-body response involving WAT, liver, and heart is required to mediate thermogenesis, especially under conditions such as fasting

Evidence-based weight management includes intensive lifestyle modification with dietary counseling and physical activity, FDA-approved medications (prescription GLP-1 agonists, phentermine-topiramate, naltrexone-bupropion, orlistat), behavioral therapy, and metabolic/bariatric surgery for eligible patients

Both peptides require combination with proper nutrition and exercise for optimal results