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Premature depletion of ovarian reserve leads to an early cessation of ovulation and subsequent infertilityevents that are intricately associated with the activation of PCD pathways ( Current clinical studies on DOR primarily focus on genome sequencing and mutation identification, while the underlying disease mechanisms and signaling pathways remain underexplored

For quantitative synthesis, effect estimates were collected when available, including HRs, 95% CI, and associated p-values