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Comparison of Ces C domains to C domain sequences in the natural product domain seeker database NaPDoS 31 revealed a distinct clustering of CesA_C1 and CesB_C3 while CesA_C2 was grouping with dual C domains and DCL (data not shown)

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Altogether, these findings support the idea that not only caffeine, but also other related components play a significant role in ameliorating behavioral and inflammatory parameters in anxiety and depression-like contexts