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Description

The independent effects included in the model were treatment, region, strata (renal function for PIONEER 5 and insulin regimen for PIONEER 8), background medication and interaction between treatment and background medication as categorical fixed effects and baseline value as a covariate, all nested within visit, and using an unstructured residual covariance matrix

Front Neuroendocr (2014) 35(1):830

Serious bleeding, which may be fatal, from drug-induced immune-mediated thrombocytopenia has been reported with exenatide use [see Warnings and Precautions (5.8)]