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A 2025 retrospective cohort study of 210 T2DM patients on oral semaglutide for 18 months found no significant association between rs6923761 or rs761387 genotypes and changes in HbA1c or BMI in that relatively well-controlled population (Candido et al., 2025) suggesting that receptor-level genotype effects may be detectable primarily in subpopulations with higher pharmacological demand or larger baseline disease severity, rather than as universal predictors

Risk Factors and Forward Sentiment Beyond the immediate trial outcomes, the financial burden of sustained R&D, combined with intensifying scrutiny on drug pricing and public health insurance reimbursement, places a ceiling on profit margins

doi: 10.1212/WNL.0000000000012894 48 JosephP.ArevaloC.OliveiraR

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